We will make presentations at "Symposium of The Japanese Society for Biomaterials", which will be held at Sendai International Center, Sendai, Japan, on October 28-29, 2024.
[Title of Presentation, 1]
Zwitterionic polymer hydrogels pioneer future biomaterials (focusing on polymer synthesis)
[Presenter]
Maki Itoh*, Youichi Matsuo, Shin Yoshida, and Madoka Takai
[Abstract]
Hydrogels based on polymers containing biocompatible zwitterionic groups are expected to be used for applications including stabilization of biomaterials, implantable bioelectronic devices, and novel medical treatments. The presentation focuses on polymerization reactions and hydrogel formation. The presentation also refers to coating of hemocompatible copolymers on various substrates. The coating reduced protein adsorption or blood coagulation with higher stability under fluidic conditions.
[Title of Presentation, 2]
Improvement of Enzyme Stability by Hydrogel Using Zwitterionic Polymers
[Presenter]
Satoshi Yamashita*, Maki Itoh, Xuejin Huang, Shin Yoshida, and Madoka Takai
[Abstract]
Gel Coat Biomaterials, Inc. is aiming to commercialize the technology based on hydrogel materials using zwitterionic polymers in the fields of biomanufacturing, preservation of biomaterials, implantable devices and novel therapies. In this presentation, we will introduce the effects of our zwitterionic polymer hydrogels on enzyme stability, activity maintenance, and thermostability. We have previously reported that immobilization of enzymes in hydrogels improves their resistance to organic solvents and thermostability. In this talk, we will introduce the principle of the stability enhancement of these enzymes. Our zwitterionic polymers can provide useful materials in a wide range of fields, such as enzyme replacement therapy and biomanufacturing, resolving stability and activity issues of enzymes.
