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Technology

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Our Technology 

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Enzymes, cells, organs, and other biomaterials have excellent functions, but their instability limits the environments, applications, and timeframes in which they can be used.

Professor Madoka Takai, Graduate School of Engineering, The University of Tokyo, has long studied zwitterionic polymers, which are biocompatible materials. The protective layer of water formed on the substrate surface by coating the substrate with this hydrophilic zwitterionic polymer inhibits adsorption of cell and protein to the surface of the substrate, thus stabilizing the bio-implantable device or artificial organ for a long time.

​Representative Paper and Patents

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  1. 1. Enzyme stability in polymer hydrogel–enzyme hybrid nanocarrier containing phosphorylcholine group, Xuejin Huang, Jincai Li, Yasuyuki Araki, Takehiko Wada, Yan Xu, and Madoka Takai, RSC Advances, 14, 18807-18814, (2024)

  2. A Modifiable, Spontaneously Formed Polymer Gel with Zwitterionic and N-Hydroxysuccinimide Moieties for an Enzymatic Biofuel Cell, Yixuan Huang, Tsukuru Masuda, and Madoka Takai, ACS Appl. Polym. Mater., 3, 2, 631-639, (2021)

  3. Patent JP7359998B2, Polymer hydrogel containing zwitterionic groups

  4. Patent JP6407513B2, Polymers for Surface Modification of Medical Materials

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