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Alliance domains

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Realizing bioprocess

We are promoting an alliance to improve the stability of enzymes, which are essential for biosynthesis and degradation. This reduces the use of organic solvents (non-fossil fuel use), thereby reducing energy consumption and by-products. By improving stability, which has been an issue, with the zwitterionic hydrogel Gel Coat™, we achieve both organic solvent resistance and high-temperature resistance. Compared to conventional chemical synthesis processes, the enzymatic method can significantly reduce CO2 emissions, shorten the process, and improve safety. This will help accelerate the synthesis of biomaterials (bioethanol, wood-based plastics) and plastic degradation.

 

Resolving problems in biomanufacturing:

  • Immobilization and stabilization of purified enzymes

  • Stabilization of cells

  • Separation of toxic products from producing microorganisms and biocatalysts using a flow synthesis system

  • Coatings for stabilizing cells

  • Biocompatible surfactants that suppress bubbles during stirring

  • Imparting resistance to organic solvents

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Bio Process

Enzyme reaction, Recovery, and Reuse

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Reaction

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repetition

Recovery of Gel Coat™ and enzymes by ultrafiltration

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column reactor

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Process Control Equipment

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Enzyme

Enzyme

Carrier

Product

Bioproduction Column

  • Gel Coat™ stabilizes enzymes towards continuous production of flow synthesis

More stable diagnostic reagents, test agents, and components

Conventional chemical synthesis and natural extraction methods make it difficult to precisely and uniformly produce antibodies, vaccines, glycans, and other substances. While enzymatic methods enable high-quality production, enzyme degradation and high costs pose challenges. Our zwitterionic hydrogel, Gel Coat™, stabilizes enzymes and enables their repeated use. This enables high-quality products produced by enzymatic methods at low cost, and can be applied to research and industrial applications such as biosensors and cell culture materials. We also offer coating technology to prevent protein adhesion to filters, flow channels, and other surfaces.

 

Resolving biological material issues:

  • Stabilization using biocompatible polymers

  • Prevention of adhesion/adsorption

  • Retention of activity

  • Business expansion through improved storage stability

  • Purification and extraction of biological materials using biocompatible amphiphilic hydrogel

  • Suppression of adsorption to extraction filters

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diagnostic

Improved stability

Gel Coat™ protection prevents
  1. denaturation at room temperature
  2. denaturation during freezing and thawing
 
Project Examples
  • Stabilization of testing and diagnostic reagents
  • Stabilization of protein-containing pharmaceuticals
  • Application to eye drops and nasal medications
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Figure: Improved stability at room temperature

Figure: Improved stability during freezing and thawing

Our hydrogel coating suppresses adhesion (fouling and adsorption) of biological substances.

Amount of biological material attached

P-4: Hydrogel coating of Gel Coat

Pluronic: Polymer for antifouling coatings and medical applications

PMEA: Polymer for antifouling coatings

P-1: Conventional MPC coating

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Biopharmaceuticals

Our Amoeba Hydrogel is immunogenicity-free polymer technology, overcoming the ABC phenomenon of PEG, improving resistance to degradative enzymes.

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Protecting and stabilizing:

  • Enzyme, DNA, exosome, unstable proteins

BioPharma

Bio Power Generator​

We are developing a bio power generator using enzymes by taking advantage of the long-term stabilization and activity enhancement of enzymes by Amoeba Hydrogel. We have already succeeded in a demonstration experiment of long-term power generation from enzymes and glucose existing in the body. 
When our bio power generator is mounted in an implantable device, it is protected by hydrogel so that it can withstand sterilization treatment and can generate electricity continuously in vivo without being charged beforehand. We are developing this technology to realize new treatment methods, such as deep brain stimulation, and photogenetic therapy for malignant tumors, which have been difficult to treat with drugs.
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